Scientific Program

Conference Series Ltd invites all the participants across the globe to attend Annual Conference on Atherosclerosis and Clinical Cardiology Philadelphia, Pennsylvania, USA.

Day 2 :

  • Special Session: Prevention and Reversal of Atherosclerosis
Location: Philadelphia
Speaker
Biography:

Bimal Chhajer, MBBS, MD is the founder of SAAOL Heart Center – the largest chain of Non Invasive Cardiology clinics in the India. He is an Ex consultant at All India Institute of Medical Sciences. He has authored about 70 books and among them a book on Reversing Heart Disease has been published in 10 different languages. He has delivered more than 5000 public lectures all over the world to educate heart patients in the last 25 years. A crusader against use of invasive treatments he has helped more than 100 thousand heart patients to avoid Bypass Surgery or Angioplasty.

Abstract:

Patient of Coronary Artery Disease (CAD) need simple, effective and user friendly guidance to prevent and/or reverse their heart conditions. With our experience of treating about 100 thousand CAD patients with lifestyle based treatments in our 48 centers across India, Bangladesh and Nepal in the last 20 years we developed a chart named “SAAOL Safety Circle”. This chart is scientifically proven and can be used by the heart patients to judge the effect of their treatment and status of disease control. It contains 16 spokes in a wheel – each spoke representing a risk factor of CAD. This list of items/parameters are Cholesterol, Triglycerides, Cholesterol/HDL ratio, BP, Sugar control, BMI, Tobacco consumption, walking, intake of fats/oils, consumption of fruits and vegetables, intake of animal foods, Yoga based exercises, Meditation and stress management. Patients need a training of 10 hours to learn a holistic program –developed by SAAOL to practice and follow this chart. This training includes heart care education, complete knowledge of Lipids, BP and Diabetes control, Zero Oil Cooking, class on “Do’s and Don’ts”, and Yoga. It takes 10 minutes to fill the chart and have been tried by tens of thousands of heart patients. There are three zones in this chart – Red (means high risk), Yellow (medium risk or prevention range) and Green ( lowest risk or reversal range). We plan to use this chart for our future program – “Heart Attack Eradication program” which will cover 10 million people.

Speaker
Biography:

Bimal Chhajer, MBBS, MD is the founder of SAAOL Heart Center – the largest chain of Non Invasive Cardiology clinics in the India. He is an Ex consultant at All India Institute of Medical Sciences. He has authored about 70 books and among them a book on Reversing Heart Disease has been published in 10 different languages. He has delivered more than 5000 public lectures all over the world to educate heart patients in the last 25 years. A crusader against use of invasive treatments he has helped more than 100 thousand heart patients to avoid Bypass Surgery or Angioplasty.

Abstract:

Coronary Artery Disease has become an epidemic in most parts of the world and in India. Palliative and temporary treatment offered by heart hospitals is expensive, inadequate and does not remove the cause of the disease. We developed a preventive program for the CAD patients who involved in Yoga, Walking, Diet, Stress reduction and optimum medical drug management. This program was named “SAAOL” or Science and Art of Living. We have trained heart patients and their spouses for a three day (10 hours a day) period in a resort – where they were educated on Diet, Zero Oil Cooking (cooking without oil), Yoga, Heart Disease, Medical management of heart disease with risk factor reduction and prescribed them a 75 minutes regimen to be followed at home. They were also prescribed modern medicines to reduce their Cholesterol, Triglycerides, Blood Pressure, Blood Glucose and Angina. The aim was to reduce all their risk factors to the best. Most of our patients were those who were waiting for Bypass surgery or Angioplasty. They were followed up for a period of 5 to 15 years. We tracked 5000 of our first 10,000 patients, who stayed near our centers and available and checked their status in 2010. The results showed that 98% were doing well and living a normal life. Their risk factors were mostly under control and they could avoid CABG/PTCA. In the last five years we have treated about 100, 000 such patients in our 48 centers spread across India along with Bangladesh,Nepal.

Break: Networking & Refreshments Break: 10:30-10:45
  • Scientific Sessions
Location: Philadelphia
Speaker

Chair

Michael Chorny

The Children Hospital of Philadelphia, USA

Session Introduction

Wenhua Ling

Sun Yat-sen University, China

Title: Anthocyanin and prevention of atherosclerosis

Time : 10:45-11:10

Speaker
Biography:

Ling Wenhua is current Dean of School of Public Health, SYSU. He obtained PhD degree in University of Eastern Finland in 1993. After then, he spent a few years (1993-1997) to be as a post-doctoral fellow in McGill University and British Columbia University of Canada. He returned to China and has been working at the Department of Nutritional Science, School of Public Health in SYSU from March 1997 till present. Now he is chairman of Nutrition Association of Guangdong Province, and the Vice Chairman of Preventive Medicine Association of Guangdong Province. His research is focusing on preventive role of nutrients, phytochemical against chronic diseases including obesity, atherosclerosis, diabetes and hepatic steatosis. He chaired more than 20 national grants including state key project from Ministry of Science and Technology, a key project from NSFC (National natural sciences fund of China), 973 project, ect. He has published 87 papers in international journals such as J Clin Invest, Circulation Res, Clin Chem, ATVB, Am J Clin Nutr and JBC. He was a tutor of 100 excellent doctoral thesis national wide in 2008. The research achievements from his group on the effect of dietary phytochemicals on atherosclerotic cardiovascular disease has won them the first award of Science and Technology of Guangdong Province and the first award of Natural Science of Education Ministry, China in 2009, respectively. Also he is granted as the national excellent teacher in 2009.

Abstract:

It has been accepted that dietary phytochemicals have various beneficial influence on human health. Among phytochemicals, anthocyanin is an important one existing in plant foods. In the recent few years, we have taken series of studies investigating the roles of anthocyanins on atherogenesis. We first observed the anti-atherosclerotic role of black rice rich in anthocyanins in animal models. Black rice supplementation (30%) for 10 weeks resulted in reduction of high dietary fat induced-formation of atherosclerotic plaques of aortas from rabbits. We then have made anthocyanin extracts (43% and 99% purity) from black rice, and examined their impacts of the extracts on atherosclerosis. Supplementation anthocyanin resulted in a remarkable inhibition of the atherosclerotic lesion in animal models. Next, we examined the effect of pure anthocyanin extract from black berry on lipid metabolism in subjects with dyslipidemia. The supplementation of anthocyanin in the dyslipidemia subjects significantly increase serum HDL-C and decrease LDL, promote the cellular cholesterol efflux to serum, and improve endothelial function and insulin resistance. Anthocyanin, Cy-3-G and Pn-3-G could in vitro promote cholesterol efflux from macrophages in dose-dependent manner. The action is closely related to the PPARγ-LXRα-ABCA1 signaling pathway. Inflammation is a main essential characteristic of atherosclerosis. Cy-3-G and Pn-3-G can also inhibit the inflammatory factors. The bioavailability of anthocyanin is very low, we examined whether anthocyanin metabolites by gut microbiota could involved in anthocyanin's activities. We found that protocatechuic acid (PCA) is a major metabolite of anthocyanin of intestinal bacteria. Further studies found that PCA contribute greatly to the reduced artery lesions in ApoE -/- mice treated by anthocyanin. The mechanism underlying the actions is via miRNA 10b pathway which up-regulates ABCA1 expression resulting in the increase of macrophage cholesterol efflux. Collectively, all of these findings demonstrate that anthocyanin compounds possess great potential in prevention and treatment of atherosclerosis.

Michael Chorny

Children’s Hospital of Philadelphia USA

Title: Accelerating endothelium recovery in injured arteries with magnetically guided cell delivery

Time : 11:10-11:35

Speaker
Biography:

Michael Chorny earned his PhD in Pharmaceutical Sciences at the Hebrew University of Jerusalem. Since 2009, he is an Assistant Professor of Pediatrics at the University of Pennsylvania and the Children’s Hospital of Philadelphia. His research focuses on development and evaluation of biodegradable nanocarriers for targeted delivery of drugs, gene vectors and cells for cardiovascular disease applications and cancer therapy.

Abstract:

Increased susceptibility to thrombosis and restenosis due to slow and often incomplete regrowth of the endothelial layer severely damaged as a result of extensive mechanical injury remains a critical limitation of interventional strategies currently used clinically to relieve atherosclerotic obstruction. Rapid endothelium recovery has the potential to both prevent the thrombotic events and limit post-angioplasty restenosis, providing the rationale for developing strategies aimed at accelerating arterial reendothelialization. In the present study, we evaluated feasibility of achieving stable homing of endothelial cells (EC) in stented arteries using a two-source magnetic guidance strategy. EC functionalized with biodegradable magnetic nanoparticles (MNP) exhibited strong magnetic responsiveness, unaltered proliferation rates, and capacity for targeted delivery effectively confining the cells to the region of stent placement in a rat model of stent angioplasty. Using bioluminescent imaging and fluorimetric tissue analysis, we showed that 1) magnetically guided cells will home and expand at the site of stent implantation, 2) targeted cell delivery realized with a brief exposure to a uniform magnetizing field of a clinically applicable strength can markedly improve site specificity as evidenced by the target:non-target ratio strongly increased in comparison to non-magnetically treated control animals, and 3) elimination of MNP used for EC functionalization will take place concomitantly with cell expansion after the completion of the targeted delivery step. The present study contributes to establishing effectiveness and safety of magnetically guided cell delivery and shows the potential of this approach for accelerating the healing of injured blood vessels and reducing vulnerability to untoward effects associated with stent angioplasty.

Yanal F. Al-Naser

Queen Alia Heart Institute, Jordan

Title: Coronary artery bypass surgery, on a 9 year old hyperlipideamic patient

Time : 11:35-12:00

Speaker
Biography:

Yanal Al-Naser is a consultant cardiac surgeon from Amman- Jordan, he graduated from the university of Jordan in 1999, and was awarded the Jordanian boards in general surgery( 2004) and cardiac surgery (2009). He was trained in Manchester –England as an adult cardiac surgeon and finished his training in 2012. He became a consultant adult cardiac surgeon in 2012 at Queen Alia Heart Institute in Jordan. He has a number of publications, and is a member of the Jordanian Cardiac society and the Royal College of Surgeons in the UK.

Abstract:

A 9 year old boy was referred to me with effort angina (NYHA class 3). He had familial hyperlipidemia and was on statins. He had a strong family history of coronary artery disease from the maternal side, where his mum, two uncles and aunt all had bypass surgeries in their twenties. His coronary angiogram showed a dominant right coronary artery with an 80% osteal lesion and a 75% ostael LAD lesion that were difficult to be stented by his treating cardiologist . His examination was unremarkable except for huge xanthomas over his elbows, knees and ankles. His cardiac echo showed a normal ventricle and valves. I operated on him and he had a left internal mammary to his LAD , and a right internal mammary to his RCA. Two year follow up showed him to be asymptomatic , with a tight lipid control. There are a few similar cases reported in literature, but this is one of the youngest to have a bilateral mammary surgey.

Speaker
Biography:

Dipak Ramji received his BSc (Hons) degree (Biochemistry) and his PhD from University of Leeds. This was followed by post-doctoral research at the EMBL (Heidelberg) and IRBM (Rome) with fellowships from the Royal Society and the EU. He joined Cardiff University in 1992 and is currently a Reader at Cardiff School of Biosciences. His research is focused on the impact of the immune and inflammatory responses on atherosclerosis with emphasis on the action of cytokines on macrophages. He has published over 80 peer-reviewed papers, reviews and book chapters. He is an Editorial Board member of 16 international journals.

Abstract:

Atherosclerosis and its complications are responsible for more deaths worldwide than any other disease. Atherosclerosis is an inflammatory disorder of medium and large arteries that involves both the innate and adaptive immune systems. The inflammatory response in atherosclerosis is orchestrated by cytokines that are produced by all the cells involved in this disease. Cytokines are generally classified as pro- or anti-atherogenic. Approaches to inhibit the actions of pro-atherogenic cytokines include neutralization via blocking antibodies or soluble decoy receptors and the use of inhibitors of intracellular signaling pathways. On the other hand, approaches for anti-atherogenic cytokines include their local delivery and the use of agents that augment their expression/actions. More than fifty cytokines have been found to be involved in atherosclerosis. It is therefore important that a thorough understanding is obtained of their actions in this disease in order to identify new therapeutic targets or approaches and validate their therapeutic potential. Research in my laboratory has focused on cytokine signaling in atherosclerosis with emphasis on macrophages, which play key roles in all stages of this disease and represent promising therapeutic targets. New insights have been obtained on the molecular mechanisms underlying the actions of interferon-gamma, transforming growth factor-beta, interleukin-33 and tumour necrosis factor-like protein 1A on key macrophage processes in atherosclerosis (e.g. foam cell formation, regulation of gene expression, amplification of the inflammatory response). These will be presented in the context of current therapies and future developments in this field.

Break: Lunch Break: 12:25-13:30